Description

4-Chloromethyl-3-Fluoro-Pyridine Hydrochloride is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique molecular structure, which allows for selective functionalization at the chloromethyl and fluorine positions, enabling the construction of complex pharmacophores and agrochemical intermediates. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Chloromethyl-3-Fluoro-Pyridine Hydrochloride
CAS No.	1357351-91-7
Molecular Formula	C6H6Cl2FN
Molecular Weight	182.02 g/mol
Synonyms	3-Fluoro-4-(chloromethyl)pyridine hydrochloride; 4-(Chloromethyl)-3-fluoropyridine hydrochloride; 3-Fluoro-4-pyridinemethanol, chloromethyl ether, hydrochloride; (3-Fluoro-4-pyridinyl)methyl chloride hydrochloride; 3-Fluoro-4-chloromethylpyridine HCl
EINECS	Contact for details

Quality Control

Every batch of 4-Chloromethyl-3-Fluoro-Pyridine Hydrochloride is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and Karl Fischer titration, to ensure compliance with exacting industry standards and customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and supply chain reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.