Description

Sodium:(2R,4S)-4-Cyclohexyl-1-[2-[[(1S)-2-Methyl-1-Propanoyloxypropoxy]-(4-Phenylbutyl)Phosphoryl]Acetyl]Pyrrolidine-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined structure. This compound is critical for the synthesis of novel therapeutic agents, particularly in the development of protease inhibitors and other targeted small-molecule drugs. It is essential for R&D laboratories and production facilities in the global pharmaceutical and biotechnology sectors seeking reliable, high-quality building blocks for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), especially for protease inhibitor candidates.
• Protease Inhibitor Research: Serves as a core structural component in the development of novel inhibitors targeting specific proteolytic enzymes.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic entities.
• Pre-clinical & Clinical Trial Material Manufacturing: Supplied under controlled conditions for the production of batches intended for non-clinical and clinical studies.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Bioconjugation & Prodrug Synthesis: Utilized in the design of prodrugs or targeted drug delivery systems due to its functionalizable groups.

Basic Information

Product Name	Sodium:(2R,4S)-4-Cyclohexyl-1-[2-[[(1S)-2-Methyl-1-Propanoyloxypropoxy]-(4-Phenylbutyl)Phosphoryl]Acetyl]Pyrrolidine-2-Carboxylate
CAS No.	1356932-15-4
Molecular Formula	C32H49NNaO8P
Molecular Weight	653.70 g/mol
Synonyms	(2R,4S)-4-Cyclohexyl-1-[2-[[(1S)-2-Methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid sodium salt; Sodium 4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]-L-prolinate; UNII-9K5V7V7K0F; 9K5V7V7K0F; (2R,4S)-1-[(2S)-2-[(4-Phenylbutoxy)(phosphono)acetyl]-4-cyclohexylpyrrolidine-2-carboxylate sodium salt; Sodium (2R,4S)-4-cyclohexyl-1-[(2S)-2-[(4-phenylbutoxy)(phosphono)acetyl]pyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems in facilities designed for advanced chemical synthesis. Every batch is subjected to comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. Our quality commitment supports regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.