Description

3-[(2R,6S)-2,6-Bis[2-(4-Methoxyphenyl)Ethyl]-1-Piperidinyl]-(2R)-1,2-Propanediol Hydrochloride is a high-purity, chiral piperidine derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block or intermediate for the development of novel therapeutic agents, where stereochemical purity is paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) or cardiovascular therapeutic areas.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing route of target APIs.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in regulatory filings.

Basic Information

Item	Details
Product Name	3-[(2R,6S)-2,6-Bis[2-(4-Methoxyphenyl)Ethyl]-1-Piperidinyl]-(2R)-1,2-Propanediol Hydrochloride
CAS No.	1356447-90-9
Molecular Formula	C26H37NO4 • HCl
Molecular Weight	464.04 g/mol (Free base: 427.58 g/mol)
Synonyms	(2R,6S)-2,6-Bis[2-(4-Methoxyphenyl)ethyl]-3-[(2R)-1,2-dihydroxypropyl]piperidine hydrochloride; (2R,6S)-2,6-Bis(2-(4-methoxyphenyl)ethyl)-3-((R)-1,2-dihydroxypropyl)piperidine HCl; 3-((2R,6S)-2,6-Bis(2-(4-methoxyphenyl)ethyl)piperidin-1-yl)-(2R)-1,2-propanediol hydrochloride; Chiral Piperidine Diol Derivative Hydrochloride
EINECS	Contact for details

Quality Control

Our 3-[(2R,6S)-2,6-Bis[2-(4-Methoxyphenyl)Ethyl]-1-Piperidinyl]-(2R)-1,2-Propanediol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.