Description

5-(4-Chlorophenyl)-3-Iodopyridin-2-Amine CAS NO 1356397-46-0 is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chlorine and iodine substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical developers for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, leveraging its halogenated aromatic system for bioactivity.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science: Acts as a monomer or functionalizing agent in the creation of organic electronic materials and advanced polymers.
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme function and cellular pathways due to its modifiable amine and halogen groups.
• Cross-Coupling Reactions: Serves as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.

Basic Information

Product Name	5-(4-Chlorophenyl)-3-Iodopyridin-2-Amine
CAS No.	1356397-46-0
Molecular Formula	C11H8ClIN2
Molecular Weight	330.55 g/mol
Synonyms	2-Amino-5-(4-chlorophenyl)-3-iodopyridine; 3-Iodo-5-(4-chlorophenyl)pyridin-2-amine; 5-(4-Chlorophenyl)-3-iodopyridin-2-ylamine; 1356397-46-0; 5-(p-Chlorophenyl)-3-iodopyridin-2-amine; 2-Pyridinamine, 5-(4-chlorophenyl)-3-iodo-
EINECS	Contact for details

Quality Control

Every batch of 5-(4-Chlorophenyl)-3-Iodopyridin-2-Amine is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.