Description

Benzyl 3,3-Difluoro-5-(Hydroxymethyl)Piperidine-1-Carboxylate CAS NO 1356339-31-5 is a high-value, multi-functional piperidine derivative featuring both a protected amine and a hydroxymethyl group. This compound serves as a critical pharmaceutical intermediate and advanced building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to introduce the difluoropiperidine scaffold, which can improve metabolic stability and binding affinity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or ligands in bifunctional degrader molecules.
• Agrochemical Synthesis: Intermediate for developing novel herbicides, fungicides, or insecticides that incorporate fluorinated heterocycles.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific molecules under cGMP or research-grade conditions.

Basic Information

Product Name	Benzyl 3,3-Difluoro-5-(Hydroxymethyl)Piperidine-1-Carboxylate
CAS No.	1356339-31-5
Molecular Formula	C14H17F2NO3
Molecular Weight	285.29 g/mol
Synonyms	1-CBz-3,3-Difluoro-5-(hydroxymethyl)piperidine; Benzyl N-(3,3-difluoro-5-(hydroxymethyl)piperidin-1-yl)formate; 3,3-Difluoro-5-(hydroxymethyl)piperidine-1-carboxylic acid benzyl ester; 1-(Benzyloxycarbonyl)-3,3-difluoro-5-(hydroxymethyl)piperidine; 3,3-Difluoro-5-(hydroxymethyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester; 1-Cbz-3,3-difluoro-5-(hydroxymethyl)piperidine; N-Carbobenzyloxy-3,3-difluoro-5-(hydroxymethyl)piperidine
EINECS	Contact for details

Quality Control

Our Benzyl 3,3-Difluoro-5-(Hydroxymethyl)Piperidine-1-Carboxylate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. For advanced applications, we offer material produced under GMP-like controls with full traceability and impurity profiling available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.