Description

3-Bromo-6-(Trifluoromethyl)Imidazo-[1,2-A]Pyridine-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its core value lies in its unique molecular architecture, combining a bromo-substituted imidazopyridine scaffold with a carboxylic acid handle and a trifluoromethyl group, enabling precise derivatization and modulation of physicochemical properties. This compound is essential for medicinal chemists and researchers in the pharmaceutical and agrochemical industries who require sophisticated intermediates for drug discovery, lead optimization, and the development of novel active ingredients.

Application

This advanced intermediate is a key precursor in the synthesis of complex molecules. Its primary applications include:

• Pharmaceutical Intermediate: A critical building block for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology, CNS disorders, and anti-infective therapies.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to introduce halogen and fluorine motifs, which can enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Serves as a sophisticated synthon in the creation of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the imidazopyridine core.
• Chemical Biology & Probe Development: The carboxylic acid group allows for convenient conjugation to biomolecules, making it useful for creating chemical probes and diagnostic tools.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalytic systems due to its electron-deficient aromatic system.

Basic Information

Product Name	3-Bromo-6-(Trifluoromethyl)Imidazo-[1,2-A]Pyridine-2-Carboxylic Acid
CAS No.	1355171-42-4
Molecular Formula	C9H4BrF3N2O2
Molecular Weight	309.04 g/mol
Synonyms	3-Bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid; 2-Imidazo[1,2-a]pyridinecarboxylic acid, 3-bromo-6-(trifluoromethyl)-; 1355171-42-4; 3-Bromo-6-trifluoromethylimidazo[1,2-a]pyridine-2-carboxylic Acid; Imidazo[1,2-a]pyridine-2-carboxylic acid, 3-bromo-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 3-Bromo-6-(Trifluoromethyl)Imidazo-[1,2-A]Pyridine-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized and verified using advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.