Description

2-(Tetrahydrofuran-3-Yl)Malonicacid is a specialized malonic acid derivative featuring a tetrahydrofuran ring substitution, serving as a versatile chiral building block in advanced organic synthesis. This compound is critical for the development of complex molecular architectures, particularly in the pharmaceutical sector where precise stereochemistry is paramount. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value intermediates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, including potential CNS-active drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the creation of advanced, stereochemically-defined active ingredients for crop protection products.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic and Industrial R&D: A valuable tool for methodological studies in organic chemistry and process chemistry optimization.

Basic Information

Product Name	2-(Tetrahydrofuran-3-Yl)Malonicacid
CAS No.	1354951-08-8
Molecular Formula	C9H12O5
Molecular Weight	200.19 g/mol
Synonyms	3-(Tetrahydrofuran-3-yl)propanedioic acid; 2-(Oxolan-3-yl)malonic acid; Tetrahydro-3-furylmalonic acid; 3-THF Malonic Acid; (Tetrahydrofuran-3-yl)malonic acid; Propanedioic acid, 2-(tetrahydro-3-furanyl)-; 1354951-08-8; CAS 1354951-08-8
EINECS	Contact for details

Quality Control

Every batch of 2-(Tetrahydrofuran-3-Yl)Malonicacid is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with exacting customer and research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.