Description

n-(2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Ethyl)Acetamide is a high-value, advanced pharmaceutical intermediate featuring a pyridine core and a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel small-molecule therapeutics, particularly in oncology and CNS disease areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester moiety is specifically designed for palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Library Synthesis: Employed in the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening.
• Process Chemistry Development: Applied in the scale-up and route scouting for efficient manufacturing of target molecules.
• Agrochemical Research: Potential use as an intermediate in the development of novel crop protection agents.
• Material Science: Can be explored in the synthesis of organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	n-(2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Ethyl)Acetamide
CAS No.	1354911-14-0
Molecular Formula	C18H30BN3O3
Molecular Weight	347.26 g/mol
Synonyms	N-[2-[[4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]amino]ethyl]acetamide; 2-Pyridineacetamide, N-[2-[[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]amino]ethyl]-; Acetamide, N-[2-[[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]amino]ethyl]-; 1354911-14-0; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-acetamidoethyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our n-(2-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylamino)Ethyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request. We adhere to cGMP guidelines for advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.