Description

n-(3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propionamide is a high-value, organoboron-containing pyridine derivative, serving as a critical advanced pharmaceutical intermediate (API) and building block in modern synthetic chemistry. Its core value lies in the protected boronic ester functional group, which enables efficient cross-coupling reactions, such as Suzuki-Miyaura couplings, for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in pharmaceutical R&D, agrochemical synthesis, and materials science who require precise and reliable building blocks for drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for forming carbon-carbon bonds in complex molecule assembly.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Used in the creation of organic electronic materials, ligands for catalysts, and functional polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): A valuable linker or component in the design of bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: Essential reagent for methodology development and synthetic route exploration in university and CRO laboratories.

Basic Information

Item	Details
Product Name	n-(3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propionamide
CAS No.	1354910-93-2
Molecular Formula	C15H23BN2O3
Molecular Weight	290.17 g/mol
Synonyms	2-Propanamide, N-[3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine propionamide; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylpicolinamide propionamide; Pinacol ester of 3-Methyl-5-boronic acid picolinamide propionamide; N-(3-Methyl-5-(pinacolatoboryl)pyridin-2-yl)propionamide; Propionamide, N-[3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]-
EINECS	Contact for details

Quality Control

Every batch of n-(3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propionamide undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.