Description

n-((R)-1-Benzyl-Piperidin-3-Yl)-2-Chloro-n-Methyl-Acetamide is a high-purity chiral building block and advanced pharmaceutical intermediate of significant interest in modern synthetic chemistry. Its value lies in its specific stereochemistry and functional groups, which make it a critical precursor for the development of novel active pharmaceutical ingredients (APIs). This compound is essential for research institutions and pharmaceutical manufacturers focused on creating new therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disorder treatments.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug discovery programs.
• Asymmetric Synthesis: Serves as a valuable building block for constructing molecules with defined stereocenters, crucial for chiral drug development.
• Preclinical & Process Chemistry: Employed in scaling up synthetic routes from laboratory to pilot plant scale for new chemical entities (NCEs).
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of proprietary compounds.
• Academic Research: Used in university and institutional labs for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	n-((R)-1-Benzyl-Piperidin-3-Yl)-2-Chloro-n-Methyl-Acetamide
CAS No.	1354001-73-2
Molecular Formula	C15H21ClN2O
Molecular Weight	280.79 g/mol
Synonyms	2-Chloro-N-[(3R)-1-benzylpiperidin-3-yl]-N-methylacetamide; (R)-N-(1-Benzylpiperidin-3-yl)-2-chloro-N-methylacetamide; 2-Chloro-N-methyl-N-[(3R)-1-(phenylmethyl)-3-piperidinyl]acetamide; n-((R)-1-Benzyl-Piperidin-3-Yl)-2-Chloro-n-Methyl-Acetamide; 1354001-73-2; UNII-9F8K1V7F4I; 9F8K1V7F4I; SCHEMBL21807027; AKOS025244065
EINECS	Contact for details

Quality Control

Our n-((R)-1-Benzyl-Piperidin-3-Yl)-2-Chloro-n-Methyl-Acetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.