Description

3-Methyl-1-(Pyridine-2-Sulfonyl)-Piperazine Hydrochloride is a high-purity, functionalized piperazine derivative designed for advanced chemical synthesis. This compound serves as a critical building block and intermediate in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a sulfonylated piperazine moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides that require a sulfonamide-linked heterocyclic scaffold for bioactivity.
• Chemical Biology Probe Development: Serves as a versatile scaffold for designing enzyme inhibitors or receptor modulators used in biochemical and pharmacological research.
• Ligand and Catalyst Preparation: The pyridine and sulfonyl groups make it a potential precursor for chelating ligands or organocatalysts in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on a commercial scale.

Basic Information

Product Name	3-Methyl-1-(Pyridine-2-Sulfonyl)-Piperazine Hydrochloride
CAS No.	1353981-04-0
Molecular Formula	C10H15N3O2S • HCl
Molecular Weight	277.77 g/mol (Free base: 241.31 g/mol)
Synonyms	1-(Pyridin-2-ylsulfonyl)-3-methylpiperazine hydrochloride; 3-Methyl-1-(2-pyridylsulfonyl)piperazine HCl; 2-[(3-Methylpiperazin-1-yl)sulfonyl]pyridine hydrochloride; N-(3-Methylpiperazin-1-yl)pyridine-2-sulfonamide hydrochloride; 1-(Pyridine-2-sulfonyl)-3-methylpiperazine hydrochloride; Piperazine, 3-methyl-1-(2-pyridinylsulfonyl)-, hydrochloride; CAS 1353981-04-0
EINECS	Contact for details

Quality Control

Our 3-Methyl-1-(Pyridine-2-Sulfonyl)-Piperazine Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.