Description

(2,3-Dihydro-Benzo[1,4]Dioxin-2-Yl)-(3-Methyl-Piperazin-1-Yl)-Methanone Hydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant interest in modern organic synthesis. This compound matters as a key building block for developing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapeutic areas. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers need it for lead optimization, process development, and scale-up synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Employed in the development and optimization of synthetic routes for potential APIs targeting specific receptors.
• Biochemical Tool Compound: Utilized in pharmacological research as a ligand or probe to study receptor binding and signal transduction pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP or non-GMP production campaigns.
• Academic Research: Used in university and institutional labs for advanced studies in heterocyclic chemistry and synthetic methodology.

Basic Information

Product Name	(2,3-Dihydro-Benzo[1,4]Dioxin-2-Yl)-(3-Methyl-Piperazin-1-Yl)-Methanone Hydrochloride
CAS No.	1353980-53-6
Molecular Formula	C15H19N2O3·HCl
Molecular Weight	308.79 g/mol (Free base: 272.33 g/mol)
Synonyms	2-(3-Methylpiperazine-1-carbonyl)-2,3-dihydro-1,4-benzodioxine hydrochloride; 1,4-Benzodioxin-2(3H)-yl(3-methyl-1-piperazinyl)methanone hydrochloride; 3-Methyl-1-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine hydrochloride; (2,3-Dihydro-1,4-benzodioxin-2-yl)(3-methylpiperazin-1-yl)methanone HCl; (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(3-methylpiperazin-1-yl)methanone hydrochloride
EINECS	Contact for details

Quality Control

Our (2,3-Dihydro-Benzo[1,4]Dioxin-2-Yl)-(3-Methyl-Piperazin-1-Yl)-Methanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.