Description

n-Cyclopropyl-N'-Piperidin-3-Ylmethyl-Pyrimidine-4,6-Diamine Hydrochloride is a high-purity, non-nucleoside pharmaceutical intermediate with a defined molecular structure. This compound matters for its critical role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop and scale up production of novel drug candidates, ensuring precise chemical synthesis and regulatory compliance.

Application

• Pharmaceutical Intermediate: Primary use as a sophisticated building block in the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Research & Development: Serves as a key reference standard and starting material in medicinal chemistry for structure-activity relationship (SAR) studies.
• Preclinical Development: Used in the scale-up and process optimization for new chemical entities (NCEs) prior to clinical trials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of advanced intermediates.
• Chemical Biology: Potential utility as a molecular probe or ligand in biochemical assays and target validation studies.
• Academic Research: Employed in university and institutional labs for synthetic methodology development and heterocyclic chemistry exploration.

Basic Information

Product Name	n-Cyclopropyl-N'-Piperidin-3-Ylmethyl-Pyrimidine-4,6-Diamine Hydrochloride
CAS No.	1353980-49-0
Molecular Formula	C14H24N6 • HCl
Molecular Weight	304.84 g/mol (Free base: 268.38 g/mol)
Synonyms	4,6-Pyrimidinediamine, N2-cyclopropyl-N4-(3-piperidinylmethyl)-, monohydrochloride; 4,6-Diamino-N-cyclopropyl-N'-(piperidin-3-ylmethyl)pyrimidine hydrochloride; 1353980-49-0; UNII-9V8I9W0R4F; 9V8I9W0R4F; n-Cyclopropyl-N'-(3-piperidinylmethyl)-4,6-pyrimidinediamine hydrochloride; 4,6-Diamino-N-cyclopropyl-N'-(3-piperidinylmethyl)pyrimidine monohydrochloride
EINECS	Contact for details

Quality Control

Our n-Cyclopropyl-N'-Piperidin-3-Ylmethyl-Pyrimidine-4,6-Diamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent specifications suitable for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.