Description

[3-(Toluene-4-Sulfonyloxymethyl)-Piperidin-1-Yl]-Acetic Acid is a high-purity synthetic intermediate of significant importance in advanced organic synthesis. This compound is valued for its functionalized piperidine scaffold and activated sulfonate ester group, which serve as key building blocks for constructing complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical development companies engaged in the creation of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Peptidomimetic Synthesis: Serves as a constrained scaffold or linker in the design and synthesis of peptide analogs and mimetics.
• Ligand and Probe Development: Employed in the creation of specialized chemical probes for biochemical and pharmacological research.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and herbicides.

Basic Information

Item	Details
Product Name	[3-(Toluene-4-Sulfonyloxymethyl)-Piperidin-1-Yl]-Acetic Acid
CAS No.	1353980-02-5
Molecular Formula	C16H23NO5S
Molecular Weight	341.42 g/mol
Synonyms	1-[2-(4-Methylphenyl)sulfonyloxyethyl]piperidine-4-acetic acid; (1-{2-[(4-Methylphenyl)sulfonyl]oxyethyl}piperidin-4-yl)acetic acid; 4-[2-(Tosyloxy)ethyl]piperidine-1-acetic acid; Tosyloxymethyl piperidine acetic acid derivative; 3-(p-Toluenesulfonyloxymethyl)-1-piperidineacetic acid; N-{2-[(4-Methylphenyl)sulfonyl]oxyethyl}glycine piperidine derivative; [3-(4-Tolylsulfonyloxymethyl)piperidin-1-yl]acetic acid
EINECS	Contact for details

Quality Control

Our [3-(Toluene-4-Sulfonyloxymethyl)-Piperidin-1-Yl]-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.