Description

4-(2-Chloro-Pyridine-3-Carbonyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis. This compound matters because it provides a critical, protected piperazine building block essential for constructing complex molecules with precise stereochemistry and functional group compatibility. Pharmaceutical R&D and process chemistry teams need it for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Protease Inhibitor Research: Used in the development of protease inhibitors, where the chloropyridine-carbonyl moiety acts as a crucial pharmacophore.
• Kinase Inhibitor Synthesis: Serves as a precursor in the creation of potent and selective kinase inhibitors for oncology research.
• Peptidomimetic Chemistry: Employed to introduce constrained piperazine motifs into peptidomimetic structures to enhance metabolic stability and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of clinical trial materials.
• Chemical Biology & Probe Development: Utilized in the design of chemical probes for target identification and validation in biological systems.

Basic Information

Product Name	4-(2-Chloro-Pyridine-3-Carbonyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353978-39-8
Molecular Formula	C17H22ClN3O3
Molecular Weight	351.83 g/mol
Synonyms	tert-Butyl 4-[(2-chloropyridin-3-yl)carbonyl]-2-methylpiperazine-1-carboxylate; 1-Boc-4-(2-chloronicotinoyl)-2-methylpiperazine; 2-Methyl-1-(tert-butoxycarbonyl)-4-(2-chloronicotinoyl)piperazine; 4-(2-Chloronicotinoyl)-2-methyl-1-piperazinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-2-methyl-4-(2-chloronicotinoyl)piperazine; 4-(2-Chloro-3-pyridinylcarbonyl)-2-methyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 2-Methyl-4-(2-chloropyridine-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Pyridine-3-Carbonyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.