Description

4-(2,3-Dihydro-Benzo[1,4]Dioxine-2-Carbonyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis and research. This compound is critical for building complex molecular architectures, offering a protected piperazine scaffold essential for developing new active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams, process chemists, and fine chemical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and other specialty drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates, especially those targeting neurological and psychiatric disorders.
• API Development: Used in the research and process development stages for creating new Active Pharmaceutical Ingredients (APIs) with complex heterocyclic structures.
• Medicinal Chemistry Research: A valuable reagent for constructing and modifying piperazine-based pharmacophores in drug discovery and lead optimization projects.
• Process Chemistry Scale-up: Employed in the optimization and kilogram-scale production of advanced intermediates for clinical trial material (CTM) and commercial API manufacturing.
• Custom Synthesis: Provides a versatile starting point for contract research and manufacturing organizations (CROs/CMOs) to produce bespoke compounds for client projects.
• Chemical Biology Probes: Can be utilized in the synthesis of specialized molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Details
Product Name	4-(2,3-Dihydro-Benzo[1,4]Dioxine-2-Carbonyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353978-12-7
Molecular Formula	C19H26N2O5
Molecular Weight	362.42 g/mol
Synonyms	tert-Butyl 4-(2,3-dihydro-1,4-benzodioxin-2-carbonyl)-2-methylpiperazine-1-carboxylate; 2-Methyl-1-(tert-butoxycarbonyl)piperazine-4-(2,3-dihydro-1,4-benzodioxine-2-carboxamide); 1-Boc-2-methylpiperazine-4-(1,4-benzodioxan-2-carboxamide); 4-(1,4-Benzodioxan-2-carbonyl)-2-methyl-1-piperazinecarboxylic acid tert-butyl ester; 4-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)-2-methyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 4-(2,3-Dihydro-Benzo[1,4]Dioxine-2-Carbonyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development under cGMP guidelines as required for advanced clinical-stage intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.