Description

4-(2-Chloro-Acetyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, particularly in the creation of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of therapeutic agents, especially within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile building block for constructing piperazine-based scaffolds in drug discovery programs.
• Protease Inhibitor Development: Employed in the research and synthesis of potential protease inhibitors for therapeutic applications.
• Kinase Inhibitor Synthesis: Serves as a precursor in the creation of novel kinase inhibitors targeting various disease pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic & Industrial R&D: Utilized in research laboratories for exploring new chemical entities and reaction methodologies.

Basic Information

Product Name	4-(2-Chloro-Acetyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353975-27-5
Molecular Formula	C12H21ClN2O3
Molecular Weight	276.76 g/mol
Synonyms	1-Boc-3-methyl-4-(2-chloroacetyl)piperazine; tert-Butyl 3-methyl-4-(2-chloroacetyl)piperazine-1-carboxylate; 4-(Chloroacetyl)-3-methyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-3-methyl-4-(2-chloroacetyl)piperazine; 3-Methyl-4-(2-chloroacetyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-3-methyl-4-(chloroacetyl)piperazine; 4-(2-Chloroacetyl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Acetyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable, and our quality systems are designed to meet the stringent requirements of global pharmaceutical supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.