Description

4-(6-Ethoxy-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a piperazine core linked to a substituted pyrimidine ring. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor development. Pharmaceutical R&D and manufacturing organizations need this precise chemical scaffold to efficiently construct novel drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of targeted kinase inhibitors and other small molecule therapeutics.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• API Synthesis: Incorporated into the final synthetic route for producing Active Pharmaceutical Ingredients (APIs) requiring a functionalized piperazine-pyrimidine moiety.
• Chemical Biology Research: Employed as a molecular probe or tool compound in biochemical and cellular assays to study specific biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific novel chemical entities.

Basic Information

Product Name	4-(6-Ethoxy-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353965-84-0
Molecular Formula	C15H24N4O3
Molecular Weight	308.38 g/mol
Synonyms	tert-Butyl 4-(6-ethoxypyrimidin-4-yl)piperazine-1-carboxylate; 1-Boc-4-(6-ethoxy-4-pyrimidinyl)piperazine; 4-(6-Ethoxy-4-pyrimidinyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 4-(6-Ethoxypyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester; BOC-4-(6-ethoxy-pyrimidin-4-yl)-piperazine; N-Boc-4-(6-ethoxypyrimidin-4-yl)piperazine
EINECS	Contact for details

Quality Control

Our 4-(6-Ethoxy-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.