Description

3-[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Peptidomimetic Synthesis: The piperidine scaffold and amide linkage make it valuable for constructing peptidomimetics and conformationally constrained analogs.
• Library Synthesis for HTS: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• Process Chemistry Development: Serves as a standardized building block for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and development services for client projects.

Basic Information

Product Name	3-[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353964-95-0
Molecular Formula	C16H20ClN3O3
Molecular Weight	337.80 g/mol
Synonyms	1-Boc-3-[(2-chloronicotinoyl)amino]piperidine; tert-Butyl 3-{[(2-chloropyridin-3-yl)carbonyl]amino}piperidine-1-carboxylate; 3-[(2-Chloronicotinoyl)amino]-1-N-Boc-piperidine; 1-(tert-Butoxycarbonyl)-3-[(2-chloropyridine-3-carbonyl)amino]piperidine; 3-Amino-1-Boc-piperidine-2-chloronicotinamide; N-(1-Boc-3-piperidinyl)-2-chloronicotinamide; 2-Chloro-N-(1-(tert-butoxycarbonyl)piperidin-3-yl)nicotinamide
EINECS	Contact for details

Quality Control

Our 3-[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.