Description

(2,3-Dihydro-Benzo[1,4]Dioxin-6-Yl)-Piperazin-1-Yl-Methanone Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined benzodioxane-piperazine scaffold. This compound is critical for research and development in medicinal chemistry, particularly for targeting specific neurological and cardiovascular pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting GPCRs and other central nervous system receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged piperazine heterocycle.
• Preclinical Development: Serves as a critical starting material or intermediate in the scale-up synthesis of compounds for toxicology and pharmacokinetic studies.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological mechanisms and target validation.

Basic Information

Product Name	(2,3-Dihydro-Benzo[1,4]Dioxin-6-Yl)-Piperazin-1-Yl-Methanone Hydrochloride
CAS No.	1353958-38-9
Molecular Formula	C14H17ClN2O3
Molecular Weight	296.75 g/mol
Synonyms	6-(Piperazine-1-carbonyl)-2,3-dihydro-1,4-benzodioxine hydrochloride; 1,4-Benzodioxin-6-yl(piperazinyl)methanone hydrochloride; 2,3-Dihydro-1,4-benzodioxin-6-yl piperazin-1-yl methanone hydrochloride; 6-(Piperazinecarbonyl)-2,3-dihydro-1,4-benzodioxine HCl; (2,3-Dihydro-1,4-benzodioxin-6-yl)(piperazin-1-yl)methanone hydrochloride
EINECS	Contact for details

Quality Control

Our (2,3-Dihydro-Benzo[1,4]Dioxin-6-Yl)-Piperazin-1-Yl-Methanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.