Description

4-(2-Aminomethyl-Piperidin-1-Ylmethyl)-Benzonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, especially for neurological targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthesis routes to construct complex molecular architectures for final APIs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of investigational new drugs.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	4-(2-Aminomethyl-Piperidin-1-Ylmethyl)-Benzonitrile Hydrochloride
CAS No.	1353954-43-4
Molecular Formula	C15H22ClN3
Molecular Weight	279.81 g/mol
Synonyms	1-[(4-Cyanophenyl)methyl]-2-(aminomethyl)piperidine hydrochloride; 2-(Aminomethyl)-1-[(4-cyanobenzyl)]piperidine hydrochloride; 4-[(2-Aminomethyl-1-piperidinyl)methyl]benzonitrile hydrochloride; 4-(2-Aminomethylpiperidin-1-ylmethyl)benzonitrile HCl; Benzonitrile, 4-[(2-(aminomethyl)-1-piperidinyl)methyl]-, hydrochloride; Piperidine, 2-(aminomethyl)-1-[(4-cyanophenyl)methyl]-, hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(2-Aminomethyl-Piperidin-1-Ylmethyl)-Benzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.