Description

4-(6-Methoxy-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a tert-butyloxycarbonyl (Boc) group and substituted with a methoxypyrimidine moiety. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The piperazine-pyrimidine structure is relevant for designing inhibitors targeting various enzymatic pathways.
• Kinase Inhibitor Synthesis: Used in the construction of heterocyclic cores found in kinase inhibitors for oncology applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic & Institutional Research: Employed in university and institutional labs for chemical biology and novel therapeutic research.

Basic Information

Product Name	4-(6-Methoxy-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353954-40-1
Molecular Formula	C14H22N4O3
Molecular Weight	294.35 g/mol
Synonyms	tert-Butyl 4-(6-methoxypyrimidin-4-yl)piperazine-1-carboxylate; 1-Boc-4-(6-methoxypyrimidin-4-yl)piperazine; 4-(6-Methoxy-4-pyrimidinyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(6-methoxypyrimidin-4-yl)piperazine; BOC-4-(6-Methoxy-pyrimidin-4-yl)-piperazine; 4-(6-Methoxypyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-(6-Methoxy-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system supports the production of material that meets the stringent requirements for pharmaceutical R&D, with capabilities for custom synthesis under cGMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.