Description

4-(4-Aminomethyl-Piperidin-1-Ylmethyl)-Benzonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique piperidine-benzonitrile scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in CNS and oncology research pipelines.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable aminomethyl and benzonitrile functional groups.
• Protease Inhibitor Synthesis: Serves as a core scaffold in the development of protease inhibitors and other enzyme-targeted therapies.
• Ligand for Receptor Targeting: Employed in the design and synthesis of ligands for G-protein-coupled receptors (GPCRs) and other biological targets.
• Fine Chemical Production: Used in custom synthesis and contract manufacturing for specialized, high-value chemical entities.
• Academic and Industrial Research: A valuable reagent for exploratory research in bioorganic chemistry and drug discovery programs.

Basic Information

Product Name	4-(4-Aminomethyl-Piperidin-1-Ylmethyl)-Benzonitrile Hydrochloride
CAS No.	1353953-90-8
Molecular Formula	C15H22N3Cl
Molecular Weight	279.81 g/mol
Synonyms	1-[(4-Cyanophenyl)methyl]-4-(aminomethyl)piperidine hydrochloride; 4-[(4-Aminomethyl-1-piperidinyl)methyl]benzonitrile hydrochloride; 4-(4-Aminomethylpiperidin-1-ylmethyl)benzonitrile HCl; Benzonitrile, 4-[(4-(aminomethyl)-1-piperidinyl)methyl]-, hydrochloride; 4-(Aminomethyl)-1-[(4-cyanobenzyl)]piperidine hydrochloride; 4-Cyano-N-(piperidin-4-ylmethyl)benzylamine hydrochloride; 1-(4-Cyanobenzyl)-4-(aminomethyl)piperidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(4-Aminomethyl-Piperidin-1-Ylmethyl)-Benzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.