Description

4-(2-Chloro-Acetyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, particularly for active pharmaceutical ingredients (APIs) targeting neurological and oncological pathways. It is essential for research institutions, CROs, and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where precise chemical structure and reliable purity are non-negotiable.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly in medicinal chemistry.
• API Synthesis: Used as a building block for constructing active pharmaceutical ingredients (APIs), especially those containing functionalized piperazine scaffolds.
• Neurological Drug Research: Employed in the research and development of compounds targeting central nervous system (CNS) disorders.
• Oncology Drug Development: Integral to the synthesis of potential chemotherapeutic agents and targeted cancer therapies.
• Process Chemistry & Scale-Up: Serves as a reliable starting material for process optimization and pilot-scale manufacturing in GMP environments.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial research quantities.

Basic Information

Product Name	4-(2-Chloro-Acetyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353947-81-5
Molecular Formula	C12H21ClN2O3
Molecular Weight	276.76 g/mol
Synonyms	tert-Butyl 4-(2-chloroacetyl)-2-methylpiperazine-1-carboxylate; 1-Boc-4-(2-chloroacetyl)-2-methylpiperazine; 2-Methyl-1-(tert-butoxycarbonyl)piperazine-4-(2-chloroacetamide); 4-(Chloroacetyl)-2-methyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-(2-chloroacetyl)-2-methyl-1-piperazinecarboxylate; N-Boc-4-(2-chloroacetyl)-2-methylpiperazine; 1353947-81-5
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Acetyl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.