Description

4-(3-Methyl-Thiophene-2-Carbonyl)-Piperazine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a versatile building block for creating novel therapeutic agents. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic research institutions focused on drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API manufacturing processes under Good Manufacturing Practice (GMP) conditions.
• Protease Inhibitor Synthesis: The piperazine-dicarboxylic acid scaffold is valuable in the development of protease inhibitors, a major class of antiviral and anticancer drugs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-commercial research quantities.

Basic Information

Product Name	4-(3-Methyl-Thiophene-2-Carbonyl)-Piperazine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	1353944-19-0
Molecular Formula	C16H22N2O5S
Molecular Weight	354.42 g/mol
Synonyms	1-Boc-4-(3-methylthiophene-2-carbonyl)piperazine-2-carboxylic acid; 1-(tert-Butoxycarbonyl)-4-[(3-methyl-2-thienyl)carbonyl]-2-piperazinecarboxylic acid; 4-(3-Methyl-2-thienylcarbonyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; Piperazine-1,3-dicarboxylic acid, 4-(3-methyl-2-thienylcarbonyl)-, 1-(1,1-dimethylethyl) ester; 1-Boc-4-(3-methylthiophene-2-carbonyl)piperazine-3-carboxylic acid (tautomer); tert-Butyl 4-(3-methylthiophene-2-carbonyl)piperazine-1,3-dicarboxylate.
EINECS	Contact for details

Quality Control

Our production of 4-(3-Methyl-Thiophene-2-Carbonyl)-Piperazine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay, related substances, and residual solvents. Our quality commitment supports compliance with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.