Description

1-(4-Cyano-Benzyl)-Piperazine-2-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined stereogenic center. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and serves as a key building block in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used to incorporate constrained piperazine carboxylic acid scaffolds into peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology Research: Employed as a tool compound or building block for developing enzyme inhibitors and receptor modulators.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Library Synthesis: Used in parallel and combinatorial chemistry to create diverse screening libraries for drug discovery programs.

Basic Information

Product Name	1-(4-Cyano-Benzyl)-Piperazine-2-Carboxylic Acid Hydrochloride
CAS No.	1353943-77-7
Molecular Formula	C13H16N3O2·HCl
Molecular Weight	281.75 g/mol
Synonyms	1-[(4-Cyanophenyl)methyl]piperazine-2-carboxylic acid hydrochloride; (S)-1-(4-Cyanobenzyl)piperazine-2-carboxylic acid hydrochloride; 1-(4-Cyanobenzyl)piperazine-2-carboxylic acid HCl; 2-Piperazinecarboxylic acid, 1-[(4-cyanophenyl)methyl]-, hydrochloride (1:1); UNII-8J3Z5M6N4P; 8J3Z5M6N4P; 1353943-77-7; 1-(4-CN-Bn)-piperazine-2-COOH·HCl
EINECS	Contact for details

Quality Control

Our 1-(4-Cyano-Benzyl)-Piperazine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP starting material applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The original container should be resealed immediately after use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.