Description

(S)-1-Boc-3-Methylpiperazine Hydrochloride is a high-purity, chiral piperazine derivative used as a critical building block in pharmaceutical synthesis. This compound is essential for medicinal chemists developing new active pharmaceutical ingredients (APIs), particularly in the areas of oncology and central nervous system (CNS) therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting protein-protein interactions.
• API Development: Used in the research and scale-up production of active pharmaceutical ingredients requiring a specific (S)-configured methylpiperazine moiety.
• Chemical Biology: Serves as a scaffold for constructing molecular probes and tool compounds in drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions.
• Peptidomimetics: Incorporated into the backbone of peptide-like molecules to enhance metabolic stability and bioavailability.

Basic Information

Product Name	(S)-1-Boc-3-Methylpiperazine Hydrochloride
CAS No.	1353006-46-8
Molecular Formula	C10H21ClN2O2
Molecular Weight	236.74 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-3-methylpiperazine hydrochloride; (S)-3-Methyl-1-Boc-piperazine hydrochloride; (S)-N-Boc-3-methylpiperazine HCl; tert-Butyl (S)-3-methylpiperazine-1-carboxylate hydrochloride; (S)-1-Boc-3-methylpiperazine HCl; (S)-1-N-Boc-3-methylpiperazine hydrochloride; (S)-3-Methylpiperazine-1-carboxylic acid tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-3-Methylpiperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.