Description

Methyl 6-Cyclopropylnicotinate is a high-purity, advanced pharmaceutical intermediate and versatile chemical building block. This compound is valued for its unique cyclopropyl-substituted pyridine core, which is critical for imparting specific biological activity and metabolic stability in drug molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides, leveraging the bioactivity of the nicotinate and cyclopropyl motifs.
• Chemical Research: Serves as a versatile precursor for further functionalization in organic synthesis, including cross-coupling reactions and ester transformations.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for metal-catalyzed reactions due to the coordinating potential of the pyridine nitrogen.
• Material Science: Potential monomer or additive in the synthesis of specialty polymers and advanced materials with tailored properties.

Basic Information

Product Name	Methyl 6-Cyclopropylnicotinate
CAS No.	1352718-60-5
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	Methyl 6-cyclopropylpyridine-3-carboxylate; 6-Cyclopropylnicotinic acid methyl ester; 3-Pyridinecarboxylic acid, 6-cyclopropyl-, methyl ester; Methyl 6-cyclopropyl-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 6-Cyclopropylnicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.