Description

tert-Butyl 2-(Pyridin-4-yl)pyrrolidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrrolidine scaffold substituted with a pyridine moiety. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially within the fields of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• API Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex active pharmaceutical ingredients.
• Ligand and Catalyst Development: Potential utility in the design of novel ligands for asymmetric catalysis or metal-organic frameworks.
• Chemical Biology Probes: Can be utilized to create molecular probes for studying biological pathways and protein interactions.
• Academic & Industrial R&D: Fundamental research in organic synthesis and heterocyclic chemistry within university and corporate settings.

Basic Information

Product Name	tert-Butyl 2-(Pyridin-4-yl)pyrrolidine-1-carboxylate
CAS No.	1352523-17-1
Molecular Formula	C14H20N2O2
Molecular Weight	248.32 g/mol
Synonyms	1-Boc-2-(4-pyridyl)pyrrolidine; tert-Butyl 2-(4-pyridinyl)-1-pyrrolidinecarboxylate; 2-(Pyridin-4-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-2-(4-pyridyl)pyrrolidine; Boc-2-(4-Pyridyl)pyrrolidine; 2-(4-Pyridyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 2-(Pyridin-4-yl)pyrrolidine-1-carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for advanced intermediates intended for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.