Description

1-(Pyrazin-2-Ylcarbonyl)Azetidine-3-Carboxylic Acid is a high-purity, heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals, particularly in the creation of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymes, leveraging the azetidine and pyrazine motifs.
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide structures for enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Library Synthesis for HTS: A valuable reagent for constructing diverse compound libraries used in high-throughput screening (HTS) campaigns.
• API Development: An intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	1-(Pyrazin-2-Ylcarbonyl)Azetidine-3-Carboxylic Acid
CAS No.	1350989-06-8
Molecular Formula	C9H9N3O3
Molecular Weight	207.19 g/mol
Synonyms	1-(Pyrazine-2-carbonyl)azetidine-3-carboxylic acid; Azetidine-3-carboxylic acid, 1-(2-pyrazinylcarbonyl)-; 3-Carboxy-1-(pyrazin-2-ylcarbonyl)azetidine; 1-(Pyrazin-2-ylcarbonyl)azetidine-3-carboxylic acid; 1350989-06-8; (Azetidin-1-yl)(pyrazin-2-yl)methanone-3-carboxylic acid; Pyrazine-azetidine carboxylic acid derivative; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 1-(Pyrazin-2-Ylcarbonyl)Azetidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.