Description

1H-Pyrazolo[3,4-B]Pyridine-3-Carboximidamide, 5-Fluoro-1-[(2-Fluorophenyl)Methyl]- is a high-purity, fluorinated pyrazolopyridine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in its precise molecular architecture, which is essential for constructing novel bioactive compounds in medicinal chemistry research and development. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Oncology Drug Development: Serves as a core scaffold for compounds targeting specific cancer pathways.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study enzyme function and cellular signaling mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for cutting-edge chemical biology and drug discovery projects.

Basic Information

Item	Detail
Product Name	1H-Pyrazolo[3,4-B]Pyridine-3-Carboximidamide, 5-Fluoro-1-[(2-Fluorophenyl)Methyl]-
CAS No.	1350653-27-8
Molecular Formula	C14H11F2N5
Molecular Weight	287.27 g/mol
Synonyms	5-Fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide; 5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide; 1-(2-Fluorobenzyl)-5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide; CAS 1350653-27-8; 1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 5-fluoro-1-[(2-fluorophenyl)methyl]-; 1350653-27-8
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-B]Pyridine-3-Carboximidamide, 5-Fluoro-1-[(2-Fluorophenyl)Methyl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring material that meets GMP-grade standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.