Description

(R)-n-(Pyrrolidin-3-Yl)Pyrazin-2-Amine Dihydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is critical for medicinal chemistry research and the development of novel therapeutic agents, particularly in the central nervous system (CNS) and oncology fields. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable source of advanced, enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates targeting various receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Ligand and Probe Development: Serves as a core structure for developing biochemical probes and tool compounds for biological target validation.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in enantioselective synthesis routes.
• Chemical Library Production: Used for the generation of diverse compound libraries for high-throughput screening (HTS).
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	(R)-n-(Pyrrolidin-3-Yl)Pyrazin-2-Amine Dihydrochloride
CAS No.	1349807-55-1
Molecular Formula	C8H13N5 · 2HCl
Molecular Weight	268.15 g/mol
Synonyms	(R)-2-(3-Aminopyrrolidin-1-yl)pyrazine dihydrochloride; (R)-N-(Pyrrolidin-3-yl)pyrazin-2-amine dihydrochloride; (3R)-1-Pyrazin-2-ylpyrrolidin-3-amine dihydrochloride; (R)-3-Amino-1-(pyrazin-2-yl)pyrrolidine dihydrochloride; (R)-1-(Pyrazin-2-yl)pyrrolidin-3-amine dihydrochloride; (R)-N-(Pyrazin-2-yl)pyrrolidin-3-amine dihydrochloride; (R)-2-(3-Aminopyrrolidin-1-yl)pyrazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-n-(Pyrrolidin-3-Yl)Pyrazin-2-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.