Description

[4-(Aminomethyl)Piperidin-1-Yl](Pyridin-2-Yl)Methanone Dihydrochloride is a high-purity, advanced pharmaceutical intermediate and building block of significant interest in modern medicinal chemistry. Its core value lies in its functionalized piperidine-pyridine hybrid structure, which is crucial for synthesizing bioactive molecules targeting the central nervous system and other therapeutic areas. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries, particularly those focused on developing novel small-molecule drugs, kinase inhibitors, and neuroactive agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile aminomethylpiperidine scaffold.
• Kinase Inhibitor Development: Serves as a core fragment in the design and synthesis of potential protein kinase inhibitors.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing active pharmaceutical ingredients (APIs) for clinical trials.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Item	Details
Product Name	[4-(Aminomethyl)Piperidin-1-Yl](Pyridin-2-Yl)Methanone Dihydrochloride
CAS No.	1349718-61-1
Molecular Formula	C12H17N3O • 2HCl
Molecular Weight	292.21 g/mol (Free base: 219.29 g/mol)
Synonyms	4-(Aminomethyl)-1-(pyridine-2-carbonyl)piperidine dihydrochloride; 1-(2-Pyridinylcarbonyl)-4-(aminomethyl)piperidine dihydrochloride; (4-(Aminomethyl)piperidin-1-yl)(pyridin-2-yl)methanone hydrochloride (1:2); 4-(Aminomethyl)-N-(pyridin-2-yl)piperidine-1-carboxamide dihydrochloride; CAS 1349718-61-1; 4-(Aminomethyl)piperidine-1-carboxylic acid 2-pyridyl ester dihydrochloride (tautomeric form); 2-[(4-(Aminomethyl)piperidin-1-yl)carbonyl]pyridine dihydrochloride
EINECS	Contact for details

Quality Control

Our [4-(Aminomethyl)Piperidin-1-Yl](Pyridin-2-Yl)Methanone Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.