Description

3-Bromo-2-Chloro-4-Fluoropyridine is a high-purity, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the fluorine and halogen atoms for bioactivity and metabolic stability.
• Material Science Research: Used in the development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Serves as a versatile substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl and heterobiaryl structures.
• Nucleophilic Aromatic Substitution: The halogen atoms provide excellent leaving groups for selective substitution reactions to introduce diverse functional groups.
• Ligand and Catalyst Development: Intermediate for synthesizing novel nitrogen-containing ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Item	Details
Product Name	3-Bromo-2-Chloro-4-Fluoropyridine
CAS No.	1349717-04-9
Molecular Formula	C5H2BrClFN
Molecular Weight	210.43 g/mol
Synonyms	2-Chloro-3-bromo-4-fluoropyridine; 4-Fluoro-3-bromo-2-chloropyridine; 3-Bromo-2-chloro-4-fluoropyridine; Pyridine, 3-bromo-2-chloro-4-fluoro-; 2-Chloro-4-fluoro-3-bromopyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Chloro-4-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP starting materials and adherence to ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.