Description

tert-Butyl [(1-Picolinoylpiperidin-4-Yl)Methyl]Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold with a picolinoyl moiety and a Boc-protected amine. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents, including potential kinase inhibitors and central nervous system (CNS) drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting protein kinases and neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis Building Block: Employed in the contract manufacturing and custom synthesis of complex molecules for preclinical and clinical trials.
• Chemical Biology Probes: Serves as a starting material for creating labeled compounds or probes used to study biological pathways and target engagement.
• Process Chemistry Development: Utilized in the scale-up and optimization of synthetic routes for potential active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl [(1-Picolinoylpiperidin-4-Yl)Methyl]Carbamate
CAS No.	1349716-50-2
Molecular Formula	C17H25N3O3
Molecular Weight	319.40 g/mol
Synonyms	Boc-4-(aminomethyl)-1-picolinoylpiperidine; tert-Butyl N-[[1-(pyridine-2-carbonyl)piperidin-4-yl]methyl]carbamate; 1-Picolinoyl-4-(Boc-aminomethyl)piperidine; 4-[[(tert-Butoxycarbonyl)amino]methyl]-1-(2-pyridinylcarbonyl)piperidine; 1349716-50-2; (1-Picolinoylpiperidin-4-yl)methyl tert-butylcarbamate; tert-Butyl [(1-(picolinoyl)piperidin-4-yl)methyl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl [(1-Picolinoylpiperidin-4-Yl)Methyl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.