Description

3-Bromo-5-Fluoro-4-Trifluoromethylpyridine is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups contribute to efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to create complex biaryl structures.
• Fluorinated Compound Library: A valuable reagent for medicinal chemistry teams building diverse screening libraries to explore structure-activity relationships (SAR).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development projects for global clients.

Basic Information

Product Name	3-Bromo-5-Fluoro-4-Trifluoromethylpyridine
CAS No.	1349708-84-4
Molecular Formula	C7H2BrF4N
Molecular Weight	255.99 g/mol
Synonyms	4-Trifluoromethyl-3-bromo-5-fluoropyridine; 5-Fluoro-3-bromo-4-(trifluoromethyl)pyridine; 3-Bromo-5-fluoro-4-(trifluoromethyl)pyridine; Pyridine, 3-bromo-5-fluoro-4-(trifluoromethyl)-; 1349708-84-4
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Fluoro-4-Trifluoromethylpyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic route. A Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), identity confirmation, and impurity profile is supplied with each shipment. Our quality commitment supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.