Description

(R)-1-(Pyridin-4-Ylmethyl)Pyrrolidin-3-Amine Trihydrochloride is a high-purity chiral amine salt, a critical building block in modern pharmaceutical synthesis. Its value lies in its role as a versatile intermediate for creating enantiomerically pure active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality intermediates for scale-up and production.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel therapeutic agents, especially in CNS-targeted drugs.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex, enantiomerically pure active pharmaceutical ingredients.
• Asymmetric Catalysis Research: Used as a ligand precursor or a chiral auxiliary in the development of new catalytic systems.
• Medicinal Chemistry & Drug Discovery: A valuable scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Supports the transition from laboratory-scale discovery to commercial manufacturing of chiral pharmaceuticals.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	(R)-1-(Pyridin-4-Ylmethyl)Pyrrolidin-3-Amine Trihydrochloride
CAS No.	1349702-35-7
Molecular Formula	C11H18N3·3HCl
Molecular Weight	307.66 g/mol (Free base: 192.28 g/mol)
Synonyms	(R)-1-((Pyridin-4-yl)methyl)pyrrolidin-3-amine trihydrochloride; (R)-1-(4-Pyridylmethyl)-3-aminopyrrolidine trihydrochloride; (R)-3-Amino-1-(pyridin-4-ylmethyl)pyrrolidine trihydrochloride; (R)-1-(Pyridin-4-ylmethyl)pyrrolidin-3-amine hydrochloride (1:3); (R)-N-[(3-Aminopyrrolidin-1-yl)methyl]pyridinium chloride
EINECS	Contact for details

Quality Control

Our (R)-1-(Pyridin-4-Ylmethyl)Pyrrolidin-3-Amine Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and development. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0% (Anhydrous basis)
Chiral Purity (HPLC)	≥98.0% ee
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.