Description

(S)-n-(Piperidin-3-Yl)Propane-2-Sulfonamide Hydrochloride is a high-purity chiral sulfonamide building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas requiring specific stereochemistry. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries. The availability of this material with assured quality and stereochemical purity is essential for accelerating drug discovery pipelines and ensuring reproducible synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) with specific stereochemical requirements.
• Medicinal Chemistry Research: Used in the design and development of novel drug candidates, especially for CNS targets, kinase inhibitors, and protease inhibitors.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate in the development of robust, scalable synthetic routes for clinical and commercial manufacturing.
• Bioconjugation & Probe Development: The sulfonamide and amine functionalities can be utilized for creating chemical probes or conjugates for biological studies.
• Library Synthesis: Employed in the generation of focused compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: A critical material supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(S)-n-(Piperidin-3-Yl)Propane-2-Sulfonamide Hydrochloride
CAS No.	1349702-29-9
Molecular Formula	C8H18N2O2S • HCl
Molecular Weight	254.76 g/mol
Synonyms	(S)-1-(Piperidin-3-yl)propane-2-sulfonamide hydrochloride; (S)-3-(2-Sulfamoylpropyl)piperidine hydrochloride; (S)-N-(Piperidin-3-yl)-2-propanesulfonamide hydrochloride; (3S)-1-Piperidinepropanesulfonamide hydrochloride; (S)-N-(3-Piperidyl)isopropylsulfonamide HCl; 1349702-29-9; (S)-Isopropylsulfonamide piperidine hydrochloride derivative
EINECS	Contact for details

Quality Control

Our (S)-n-(Piperidin-3-Yl)Propane-2-Sulfonamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) are provided with each shipment, detailing results for assay, chiral purity, and impurity profiles via validated methods such as HPLC and NMR. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under anhydrous conditions if specified. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.