Description

3-Piperidinecarboxylic Acid, 2-[4-(Cyclopentylamino)Phenyl]-1-(2-Fluoro-6-Methylbenzoyl)-, (2R,3S)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate (API intermediate) with the CAS registry number 1346623-11-7. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in synthesizing novel therapeutic agents. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and development of new drugs targeting complex diseases.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral building block in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot and commercial production scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	3-Piperidinecarboxylic Acid, 2-[4-(Cyclopentylamino)Phenyl]-1-(2-Fluoro-6-Methylbenzoyl)-, (2R,3S)-
CAS No.	1346623-11-7
Molecular Formula	C25H29FN2O3
Molecular Weight	424.51 g/mol
Synonyms	(2R,3S)-2-[4-(Cyclopentylamino)phenyl]-1-(2-fluoro-6-methylbenzoyl)-3-piperidinecarboxylic acid; (2R,3S)-Relacorilant Intermediate; GSK-2982772 Intermediate; CORT-125134 Intermediate; Selective Glucocorticoid Receptor Modulator Intermediate; (2R,3S)-2-(4-(Cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)piperidine-3-carboxylic acid; Relacorilant (CORT125134) Impurity; GSK2982772 Impurity
EINECS	Contact for details

Quality Control

Our 3-Piperidinecarboxylic Acid, 2-[4-(Cyclopentylamino)Phenyl]-1-(2-Fluoro-6-Methylbenzoyl)-, (2R,3S)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2R,3S)-isomer
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.