Description

5,6-Diamino-2,4-Dihydroxypyrimidine-13C2, Hydrochloride Salt is a stable, isotopically labeled derivative of a key pyrimidine intermediate, essential for advanced research and development. This compound is specifically valued for its role as a stable isotope-labeled building block in the synthesis of complex molecules for analytical and diagnostic applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and life science industries who require high-purity, labeled compounds for metabolic studies, tracer synthesis, and mass spectrometry-based quantification.

Application

• Stable Isotope Labeled Standard (SILS): Serves as a critical internal standard for the accurate quantification of pyrimidine derivatives and related metabolites in complex biological matrices using LC-MS/MS and GC-MS.
• Pharmaceutical Research & Development: Used as a labeled precursor in the synthesis of isotopically labeled drug candidates for pharmacokinetic (PK), pharmacodynamic (PD), and absorption, distribution, metabolism, and excretion (ADME) studies.
• Metabolic Pathway Tracing: Enables the detailed tracing and elucidation of biochemical pathways in both in vitro and in vivo systems due to the incorporation of 13C atoms.
• Diagnostic Reagent Synthesis: A key intermediate in the development of advanced diagnostic assays and imaging agents where isotopic labeling is required for sensitivity and specificity.
• Agrochemical Research: Employed in the development and environmental fate studies of new agrochemicals, helping to understand degradation pathways and metabolite identification.
• Biochemical Research: Utilized in enzymatic studies and as a probe to investigate the mechanisms of action of various enzymes involved in nucleotide synthesis and metabolism.

Basic Information

Product Name	5,6-Diamino-2,4-Dihydroxypyrimidine-13C2, Hydrochloride Salt
CAS No.	1346605-20-6
Molecular Formula	C413C2H8N4O2 • HCl
Molecular Weight	Contact for details
Synonyms	2,4-Dihydroxy-5,6-diaminopyrimidine-13C2 hydrochloride; 5,6-Diaminouracil-13C2 hydrochloride; 5,6-Diamino-2,4(1H,3H)-pyrimidinedione-13C2 hydrochloride; Isotopically labeled 5,6-diaminouracil HCl; [13C2]-5,6-Diamino-2,4-dihydroxypyrimidine hydrochloride; 13C2-Labeled DAHP hydrochloride; 5,6-Diamino-1H-pyrimidine-2,4-dione-13C2 hydrochloride
EINECS	Contact for details

Quality Control

Our 5,6-Diamino-2,4-Dihydroxypyrimidine-13C2, Hydrochloride Salt is manufactured under strict quality control protocols to ensure the highest standards of isotopic enrichment and chemical purity, critical for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic purity (>99 atom % 13C), and chemical assay. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99 atom % 13C
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.