Description

5-Chloro-2-Methoxy-Benzoic Acid-13C,D3 is a stable isotope-labeled analog of 5-chloro-2-methoxybenzoic acid, specifically enriched with carbon-13 and deuterium. This compound is essential for use as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability in analytical measurements. It is primarily needed by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal standard for the LC-MS/MS quantification of 5-chloro-2-methoxybenzoic acid and related metabolites in biological matrices (plasma, serum, urine).
• Critical reagent in drug metabolism and pharmacokinetics (DMPK) studies for tracking parent drug and metabolite concentrations.
• Use in bioanalytical method development and validation to ensure regulatory compliance (FDA, EMA) for new drug applications.
• High-purity reference material for calibrating analytical instruments in pharmaceutical quality control laboratories.
• Tool for conducting absolute bioavailability and mass balance studies in clinical trials.
• Research applications in environmental analysis for tracing the degradation pathways of similar chlorinated aromatic compounds.

Basic Information

Product Name	5-Chloro-2-Methoxy-Benzoic Acid-13C,D3
CAS No.	1346600-36-9
Molecular Formula	C713C1H3D3ClO3
Molecular Weight	~194.60 g/mol
Synonyms	5-Chloro-2-methoxybenzoic-13C,3,5,6-d3 acid; 2-Methoxy-5-chlorobenzoic-13C,3,5,6-d3 acid; 5-Chloro-o-anisic-13C,3,5,6-d3 acid; 5-Chloro-2-methoxybenzoic acid (phenyl-13C,3,5,6-d3); 5-Chloro-2-methoxybenzoic acid-13C,d3; 5-Chloro-2-methoxy-[13C6]benzoic-3,5,6-d3 acid; [13C6, 3,5,6-2H3]-5-Chloro-2-methoxybenzoic acid
EINECS	Contact for details

Quality Control

Every batch of our 5-Chloro-2-Methoxy-Benzoic Acid-13C,D3 is manufactured under strict quality systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity verified by NMR (1H, 13C), mass spectrometry, and HPLC. Certificates of Analysis (COA) are provided with each shipment, detailing assay, isotopic enrichment, and impurity profiles to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C; ≥98 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.