Description

2-[2-Fluoro-4-(4-Methylpiperazino)Phenyl]-1,3-Dioxolane is a high-purity, advanced pharmaceutical intermediate featuring a unique fluorinated phenyl-dioxolane structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research, where its fluorine atom and piperazine moiety are key pharmacophores. It is an essential building block for medicinal chemists and process development scientists in pharmaceutical R&D and manufacturing seeking to develop next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly for CNS disorders and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorinated aromatic and heterocyclic components.
• Process Chemistry & Scale-Up: Serves as a critical raw material for process development and the commercial-scale manufacturing of target APIs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	2-[2-Fluoro-4-(4-Methylpiperazino)Phenyl]-1,3-Dioxolane
CAS No.	1346597-60-1
Molecular Formula	C14H19FN2O2
Molecular Weight	266.32 g/mol
Synonyms	2-(2-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1,3-dioxolane; 1,3-Dioxolane, 2-[2-fluoro-4-(4-methyl-1-piperazinyl)phenyl]-; 2-(2-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)-[1,3]dioxolane; 4-(2-(1,3-Dioxolan-2-yl)-5-fluorophenyl)-1-methylpiperazine; 1-Methyl-4-[4-(1,3-dioxolan-2-yl)-3-fluorophenyl]piperazine
EINECS	Contact for details

Quality Control

Our 2-[2-Fluoro-4-(4-Methylpiperazino)Phenyl]-1,3-Dioxolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles suitable for pharmaceutical intermediate applications, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.