Description

2-Difluoromethyl-Nicotinic Acid Ethyl Ester is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethyl group, enabling the development of novel compounds with enhanced properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the fluorinated moiety for improved bioactivity and stability.
• Material Science Research: Serves as a precursor for functionalized ligands and organic frameworks used in catalysis and advanced materials.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for studying biological mechanisms and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Difluoromethyl-Nicotinic Acid Ethyl Ester
CAS No.	1346541-56-7
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	Ethyl 2-(difluoromethyl)nicotinate; 2-(Difluoromethyl)pyridine-3-carboxylic acid ethyl ester; Nicotinic acid, 2-(difluoromethyl)-, ethyl ester; 3-Pyridinecarboxylic acid, 2-(difluoromethyl)-, ethyl ester; Ethyl 2-(difluoromethyl)-3-pyridinecarboxylate; 2-Difluoromethyl-3-ethoxycarbonylpyridine
EINECS	Contact for details

Quality Control

Our 2-Difluoromethyl-Nicotinic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.