Description

2-Bromo-5-(2,2,2-Trifluoroethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the pyridine and trifluoroethyl motifs.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and functional polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the reactive bromine substituent.
• Fluorine Chemistry: The 2,2,2-trifluoroethyl group makes it a valuable synthon for introducing fluorine atoms to modulate lipophilicity, metabolic stability, and bioavailability in lead compounds.

Basic Information

Product Name	2-Bromo-5-(2,2,2-Trifluoroethyl)Pyridine
CAS No.	1346531-45-0
Molecular Formula	C7H5BrF3N
Molecular Weight	240.02 g/mol
Synonyms	5-(2-Bromo-5-pyridinyl)-1,1,1-trifluoroethane; 2-Bromo-5-(2,2,2-trifluoroethyl)pyridine; 2-Bromo-5-(trifluoroethyl)pyridine; Pyridine, 2-bromo-5-(2,2,2-trifluoroethyl)-; 1346531-45-0; 2-Br-5-TFEP
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(2,2,2-Trifluoroethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.