Description

4,5-Dichloro-6-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound is engineered to serve as a critical intermediate in the development of complex molecules, offering unique reactivity due to its halogenated and silyl-protected structure. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Development: Used to construct complex heterocyclic cores for new-generation pesticides and herbicides.
• Material Science Research: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology Probes: Utilized in the creation of tagged molecules for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Directed Functionalization: The triisopropylsilyl (TIPS) group acts as a protective and directing agent for further selective chemical modifications on the pyrrolopyridine scaffold.

Basic Information

Product Name	4,5-Dichloro-6-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1346447-26-4
Molecular Formula	C17H23Cl2IN2Si
Molecular Weight	497.27 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 4,5-dichloro-6-iodo-1-[(1-methylethyl)silyl]-, TIPS-4,5-Dichloro-6-iodo-1H-pyrrolo[2,3-b]pyridine; 4,5-Dichloro-6-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Triisopropylsilyl)-4,5-dichloro-6-iodo-1H-pyrrolo[2,3-b]pyridine; 1346447-26-4
EINECS	Contact for details

Quality Control

Our production of 4,5-Dichloro-6-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.