Description

4-Chloro-3-Iodo-1H-Pyrrolo[2,3-B]Pyridin-5-Ol is a high-purity halogenated pyrrolopyridine derivative, a crucial advanced intermediate in modern pharmaceutical and agrochemical research. Its unique molecular scaffold, featuring both chloro and iodo substituents, makes it a versatile building block for constructing complex bioactive molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel kinase inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for kinase-targeted therapies in oncology and inflammatory diseases.
• Agrochemical Research: Serves as a building block for creating new active ingredients in crop protection products, leveraging its heterocyclic core for bioactivity.
• Chemical Biology Probe Development: Used in the design and synthesis of molecular probes to study enzyme function and cellular signaling pathways.
• Material Science Precursor: Potential precursor for the synthesis of specialized organic electronic materials or ligands for catalytic systems.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and scale-up projects for client molecules.

Basic Information

Product Name	4-Chloro-3-Iodo-1H-Pyrrolo[2,3-B]Pyridin-5-Ol
CAS No.	1346447-24-2
Molecular Formula	C7H4ClIN2O
Molecular Weight	294.48 g/mol
Synonyms	4-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridin-5-ol; 5-Hydroxy-4-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridin-5-ol, 4-chloro-3-iodo-; 4-Chloro-3-iodo-5-hydroxy-1H-pyrrolo[2,3-b]pyridine; 1346447-24-2 (CAS); Halogenated Pyrrolopyridine Derivative
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-3-Iodo-1H-Pyrrolo[2,3-B]Pyridin-5-Ol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency essential for sensitive R&D and scale-up work. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.