Description

tert-Butyl ((7-Chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl)methyl)carbamate is a high-purity, advanced pharmaceutical intermediate featuring a carbamate-protected amine group on a fused dioxino-pyridine scaffold. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly those targeting the central nervous system.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a protected amine synthon for constructing final active pharmaceutical ingredients, especially in heterocyclic chemistry.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for studying novel organic reactions and synthesizing biologically active molecules.

Basic Information

Item	Details
Product Name	tert-Butyl ((7-Chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl)methyl)carbamate
CAS No.	1346447-18-4
Molecular Formula	C14H17ClN2O4
Molecular Weight	312.75 g/mol
Synonyms	Boc-8-AMC-7-Cl-DHP; tert-Butyl N-[(7-chloro-2,3-dihydro-1,4-dioxino[2,3-b]pyridin-8-yl)methyl]carbamate; 8-[(tert-Butoxycarbonylamino)methyl]-7-chloro-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 7-Chloro-8-((((tert-butoxy)carbonyl)amino)methyl)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine; (7-Chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl)methyl carbamic acid tert-butyl ester; N-Boc-7-chloro-8-aminomethyl-2,3-dihydro-1,4-dioxino[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl ((7-Chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl)methyl)carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.