Description

6-Iodo-3,4-Dihydro-2H-Pyrano[2,3-B]Pyridine is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique fused pyranopyridine scaffold and reactive iodine substituent, which enable precise molecular construction for complex target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets, leveraging its fused bicyclic structure.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, where the iodine atom facilitates further functionalization.
• Material Science Building Block: Employed in the creation of advanced organic electronic materials, ligands for catalysis, and specialty polymers.
• Cross-Coupling Reactions: Serves as a versatile electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) for carbon-carbon bond formation.
• Medicinal Chemistry SAR Studies: Utilized to explore structure-activity relationships (SAR) by introducing the iodine handle for further derivatization or as a bioisostere.
• Chemical Biology Probes: Acts as a starting point for synthesizing molecular probes and tags for studying biological systems.

Basic Information

Product Name	6-Iodo-3,4-Dihydro-2H-Pyrano[2,3-B]Pyridine
CAS No.	1346446-85-2
Molecular Formula	C8H8INO
Molecular Weight	261.06 g/mol
Synonyms	6-Iodo-3,4-dihydro-2H-pyrano[2,3-b]pyridine; 2H-Pyrano[2,3-b]pyridine, 6-iodo-3,4-dihydro-; 6-Iododihydropyranopyridine; 6-Iodo-2H,3H,4H-pyrano[2,3-b]pyridine; 1346446-85-2; AI3-72935; ZINC000103223707; SCHEMBL21842527
EINECS	Contact for details

Quality Control

Our 6-Iodo-3,4-Dihydro-2H-Pyrano[2,3-B]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.