Description

Methyl 5-(Trifluoromethyl)Pyrazine-2-Carboxylate is a high-value trifluoromethylated pyrazine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in introducing the metabolically stable and lipophilic trifluoromethyl group into complex molecular architectures, significantly altering their biological activity and physicochemical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances efficacy and environmental stability.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronics, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and the unique properties imparted by the CF3 group in medicinal and materials chemistry.

Basic Information

Product Name	Methyl 5-(Trifluoromethyl)Pyrazine-2-Carboxylate
CAS No.	1346252-26-3
Molecular Formula	C7H5F3N2O2
Molecular Weight	206.12 g/mol
Synonyms	Methyl 5-(trifluoromethyl)pyrazine-2-carboxylate; 5-(Trifluoromethyl)pyrazine-2-carboxylic acid methyl ester; Methyl 5-(trifluoromethyl)-2-pyrazinecarboxylate; 2-Pyrazinecarboxylic acid, 5-(trifluoromethyl)-, methyl ester; Methyl 5-trifluoromethylpyrazine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-(Trifluoromethyl)Pyrazine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.