Description

(3R,3As,3Bs,6As,8As,9Ar)-Octahydro-3-Hydroxy-3,8A-Dimethyl-6-Methylene-1H-Oxireno[8,8A]Azuleno[4,5-B]Furan-5(6H)-One is a high-purity, complex sesquiterpene lactone derivative with a fused oxirenoazulene structure. This compound is valued as a critical advanced intermediate for the synthesis of novel bioactive molecules in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical sectors for building complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of potential drug candidates, particularly in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis due to its complex, polycyclic framework.
• Agrochemical Development: Investigated as a precursor for novel, biologically active compounds with potential pesticidal or herbicidal properties.
• Organic Synthesis Reference Standard: Employed as a high-purity standard for analytical method development and validation in QC laboratories.
• Academic & Institutional Research: Utilized in universities and research institutes for studies in total synthesis, natural product chemistry, and catalysis.
• Fine Chemical Synthesis: Acts as a specialty intermediate for producing flavors, fragrances, or other high-value chemicals requiring its unique stereochemistry.

Basic Information

Product Name	(3R,3As,3Bs,6As,8As,9Ar)-Octahydro-3-Hydroxy-3,8A-Dimethyl-6-Methylene-1H-Oxireno[8,8A]Azuleno[4,5-B]Furan-5(6H)-One
CAS No.	1343403-10-0
Molecular Formula	C15H20O4
Molecular Weight	264.32 g/mol
Synonyms	8α-Hydroxy-4,5α-epoxy-7(11)-guaien-12,8-olide; 8α-Hydroxy-4,5α-epoxy-7(11)-guaiaen-12,8-olide; Guaianolide derivative; Oxireno[8,8a]azuleno[4,5-b]furan-5(6H)-one, octahydro-3-hydroxy-3,8a-dimethyl-6-methylene-, (3R,3aS,3bS,6aS,8aS,9aR)-; Sesquiterpene lactone epoxide; Advanced guaianolide intermediate
EINECS	Contact for details

Quality Control

Our (3R,3As,3Bs,6As,8As,9Ar)-Octahydro-3-Hydroxy-3,8A-Dimethyl-6-Methylene-1H-Oxireno[8,8A]Azuleno[4,5-B]Furan-5(6H)-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to light and oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.